2021 New Orleans Saints Schedule
| 1 | Sept. 12 | Green Bay Packers | 3:25 p.m. |
| 2 | Sept. 19 | at Carolina Panthers | 12:00 p.m. |
| 3 | Sept. 26 | at New England Patriots | 12:00 p.m. |
| 4 | Oct. 3 | New York Giants | 12:00 p.m |
| 5 | Oct. 10 | at Washington F.T. | 12:00 p.m. |
| 6 | ------- | BYE | -------- |
| 7 | Oct. 25 | at Seattle Seahawks | 7:15 p.m. |
| 8 | Oct. 31 | Tampa Bay Buccaneers | 3:25 p.m. |
| 9 | Nov. 7 | Atlanta Falcons | 12:00 p.m. |
| 10 | Nov. 14 | at Tennessee Titans | 12:00 p.m. |
| 11` | Nov. 21 | at Philadelphia Eagles | 12:00 p.m. |
| 12 | Nov. 25 | Buffalo Bills | 7:20 p.m. |
| 13 | Dec. 2 | Dallas Cowboys | 7:20 p.m. |
| 14 | Dec. 12 | at New York Jets | 12:00 p.m. |
| 15 | Dec. 19 | at Tampa Bay Buccaneers | 7:20 p.m. |
| 16 | Dec. 27 | Miami Dolphins | 7:15 p.m. |
| 17 | Jan. 2 | Carolina Panthers | 12:00 p.m. |
| 18 | Jan. 9 | at Atlanta Falcons | 12:00 p.m. |
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